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These range from FDA-approved medications, such as GLP-1 receptor agonists (Wegovy, Zepbound) for weight loss, to unregulated compounds with minimal or no human safety data

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The results of cardiovascular outcome trials of long-acting GLP-1RAs (liraglutide, semaglutide) demonstrated cardiovascular benefits in subjects with type 2 diabetes mellitus and a high risk of cardiovascular disease